A DNA Translation Device
The translation device is shown in four panels below. (a) Recapitulates the PX-JX2 device.
(b) Shows the translation device.
It consists of a diamond on the left and two double diamonds to its
right. The components are
separated by two different PX- JX2 devices. Thus, there are four states to the
device, depending on how the devices are set. The key point is that the numbers flanking the gaps on top
(shown as 1,2 and 4,6) can be changed by changing the state of the whole
molecule. (c) Illustrates the
operation of the device. The
device is set in the first step so that the left gap is 1,2 and the right gap
is 4,7, by putting the left PX-JX2 device
into the PX state and the right one into the JX2 state. The system is exposed to double
crossover (DX) molecules that contain sticky ends complementary to the gaps, as
well as an initiator (black) that is on the left of all products. In a fashion similar to the way that
tRNA molecules are selected by a ribosome and message combination, the DX
molecules are selected by the device. They are then ligated together, and the final strand selected
for sequencing. (d) Illustrates
the four products possible; each is obtained depending on the setting of the
device. This is translation,
because the strands that control the PX-JX2 device
are related to the products by an arbitrary code.
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