In
each of the four cases, two PX-JX2 cassettes that face each other
are shown anchored in a blue origami array beneath them by two green
domains. The sticky ends are
indicated as A and B (left), or C and D (right). Their relative positions are established by the state (PX or
JX2) of the cassettes.
The four different capture molecules are shown to have sticky ends with
primed labels that are complementary to the pairs of sticky ends on the
cassettes. The pattern is
established by the top domain of the capture molecules.
The
origami, cassettes and the capture molecules are shown schematically in (a)
below, and in atomic force micrographs in (b) below.
There
is an inherent error rate, because a half-right molecule can bind, as well as a
completely wrong molecule. This is
corrected by the error-free binding protocol below.
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