In each of the four cases, two PX-JX2 cassettes that face each other are shown anchored in a blue origami array beneath them by two green domains. The sticky ends are indicated as A and B (left), or C and D (right). Their relative positions are established by the state (PX or JX2) of the cassettes. The four different capture molecules are shown to have sticky ends with primed labels that are complementary to the pairs of sticky ends on the cassettes. The pattern is established by the top domain of the capture molecules.
The origami, cassettes and the capture molecules are shown schematically in (a) below, and in atomic force micrographs in (b) below.
There is an inherent error rate, because a half-right molecule can bind, as well as a completely wrong molecule. This is corrected by the error-free binding protocol below.
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