PRESENTATION TOPICS

G25.1815

MACROMOLECULAR STRUCTURE

SPRING 1999

INSTRUCTIONS FOR PRESENTATIONS:

[1] EVERYBODY WILL HAVE A TOTAL OF 25 MINUTES. PLEASE COME TO CLASS AS EARLY AS POSSIBLE, BECAUSE IF EVERYONE IS THERE WE CAN START. WE WILL START WHEN EVERYONE IS THERE, OR 2:50, WHICHEVER COMES FIRST.

[2] PLAN TO SPEND NO MORE THAN 20 MINUTES ON YOUR TALK. THE REST OF THE TIME IS FOR DISCUSSION. I WILL CUT YOU OFF AFTER 20 MINUTES. YOU ARE RESPONSIBLE FOR PRESENTING EVERY PAPER IN YOUR ASSIGNMENT.

[3] YOU SHOULD USE OVERHEADS TO ILLUSTRATE THE IMPORTANT FIGURES AND POINTS IN THE PAPER. THESE SHOULD BE DERIVED FROM THE ORIGINAL PUBLICATION, NOT FROM THE REDUCED B&W XEROX IN THE LIBRARY. IF FIGURES ARE IN COLOR IN THE ORIGINAL, YOUR OVERHEADS SHOULD BE IN COLOR, AS WELL. START LOOKING FOR YOUR ARTICLES NOW. IF THEY ARE HARD TO FIND, TELL ME. IF YOU START MAKING YOUR OVERHEADS THE NIGHT BEFORE YOUR TALK, YOU MAY HAVE ONLY GARBAGE TO SHOW. POINT ON THE SCREEN, NOT ON THE PROJECTOR.

[4] EVERYBODY IS RESPONSIBLE FOR EVERY PAPER. THAT IS WHY WE HAVE 5 MINUTES OF DISCUSSION SCHEDULED. YOU WILL BE GRADED ON YOUR DISCUSSION PARTICIPATION. EVERYBODY STARTS WITH A DISCUSSION GRADE OF 'C', A FAILING GRADE FOR A GRADUATE STUDENT. HOWEVER, IF YOU ASK A DUMB QUESTION, INDICATING THAT YOU HAVE NOT READ THE ARTICLE, YOU WILL GET A GRADE BELOW 'C'. GOOD QUESTIONS DO NOT REPEAT WHAT THE SPEAKER JUST SAID, BUT INVOLVE CLARIFICATION OF POINTS RAISED. IF I AM UNSATISFIED WITH THE QUALITY OF DISCUSSION, I WILL GIVE A FINAL EXAM ON THE CONTENT OF THE PAPERS. OTHERWISE I WON'T.

[5] PRACTICE YOUR TALK AT LEAST 30 TIMES!!!

(1) TUESDAY, APRIL 20 — Angelo Nicolleta

RNA AND METALS

  1. Basu, S., Rambo, R.P., Strauss-Soukup, J., Cate, J.H., Ferre-D'Amare, A.R., Strobel, S.A. & Doudna, J.A., A speciric monovalent metal ion integral to the AA platform of the RNA tetraloop receptor, Nature Struct. Biol. 5, 986-992 (1998).

2. Ippolito, J.A. & Steitz, T.A., A 1.3 A resolution crystal structure of the HIV-1 trans-activation response region RNA stem reveals a metal ion-dependent bulge conformation, Proc. Nat. Acad. Sci. (USA) 95, 9819-9824 (1998).

 

(2) TUESDAY, APRIL 20 — Tian Wu

APTAMERS AND RYBOZYMES

1. Lan, N., Howrey, R.P., Lee, S.-W., Smith, C.A. & Sullenger, B.A., Ribozyme-mediated repair of sickel b-globin mRNAs in erythrocyte precursors, Science 280, 1593-1596 (1998).

2. Rowsell., S., Stonehouse, N.J., Convery, M.A., Adams, C.J., Ellington, A.D., Hirao, Ichiro, Peabody, D.S., Stockley & Phillips, S.E.V., Crystal structures of a series of RNA aptamers complexed to the same protein target, Nature Struct. Biol. 5, 970-975 (1998).

 

(3) TUESDAY, APRIL 20 — Jing Huang

RUVA CRYSTAL STRUCTURES

1. Hargreaves, D., Rice, D.W., Sedelnikova, S.E., Artymiuk, P.J., Lloyd, R.G. & Rafferty, J.B., Crystal structure of E. Coli RuvA with bound DNA Holliday junction at 6 A resolution, Nature Struct. Biol. 5, 441-446 (1998).

2. Roe, S.M., Barlow, T., Brown, T., Oram, M., Keeley, A., Tsaneva, I.R. & Pearl, L.H., Crystal structure of an octameric RuvA-Holliday junction complex, Mol. Cell 2, 361-372 (1998).

 

(4) TUESDAY, APRIL 20 — Jeff Birac

ICOSAHEDRALLY-BASED SYSTEMS

1. Grimes, J.M., Burroughs, J.N., Gouet, P., Diprose, J.M., Malby, R., Zientara, S., Mertens, P.P.C. & Stuart, D.I., The atomic structure of the bluetongue virus core, Nature 395, 470-478 (1998).

2. Izard, T., Aevarsson, A., Allen, M.D., Westphal, A.H., Perham, R.N., de Kok, A. & Hol, W.G.J., Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes, Proc. Nat. Acad. Sci. (USA) 96, 1240-1245 (1999).

 

(5) THURSDAY, APRIL 22 — Jun Wang

DNA CLUSTERS

1. Mucic, R.C., Storhoff, J.J., Mirkin, C.A. & Letsinger, R.L., DNA-directed synthesis of binary nanoparticl network materials, J. Am. Chem. Soc. 120, 12674-12675 (1998).

2. Wang, J., Jiang, M., Nilsen, T.W. & Getts, R.C., Dendritic nucleic acid probes for DNA biosensors, J. Am. Chem. Soc. 120, 8281-8282 (1998).

 

(6) THURSDAY, APRIL 22 — Xuanwei Huang

OTHER BIOLOGICAL POLYMERS

1. Cowman, M.K., Li, M. & Balazs, E.A., Tapping mode atomic force microscopy of hyaluronan: Extended and intramolecularly interaction chains, Biophys. J. 75, 2030-2037 (1998).

2. Mcdaniel, R., Thamchaipenet, A., Gustafsson, C., Fu, H., Betlach, M., Betlach, M. & Ashley, G., Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel 'unnatural' natural products, Proc. Nat. Acad. Sci. (USA) 96, 1846-1851 (1999).

(7) THURSDAY, APRIL 22 — Min Wu

ENZYME ENGINEERING

1. Sinha, S.C., Barbas III, C.R., & Lerner, R.A., The antibody catalysis route to the total synthesis of epothilones, Proc. Nat. Acad. Sci. (USA) 95, 14603-14608 (1998).

2. Pedersen, H., Hölder, S., Sutherlin, D.{., Schwitter, U., King, D.S. & Schultz, P.G., A method for directed evolution and functional cloning of enzymes, Proc. Nat. Acad. Sci. (USA) 95, 10523-10528 (1998).

 

(8) THURSDAY, APRIL 29 — Xiaohu Gao

SINGLE MOLECULE METHODS

1. Marszalek, P.E., Oberhauser, A.F., Pang, Y.-P., & Fernandez, J.M., Polysaccharide elasticity governed by chair-boat transitions of the glucopyranose ring, Nature 396, 661-664 (1998).

2. Allemand, J.F., Bensimon, D., Lavery, R. & Crouquette, V., Stretched and overwound DNA forms a Pauling-like structure with exposed bases, Proc. Nat. Acad. Sci. (USA) 95, 14152-14157 (1998).

 

 

 

(9) THURSDAY, APRIL 29 — Wanqiu Shen

ROLES OF DNA FUNCTIONAL GROUPS

1. Kielkopf, C.L., White, S., Szewczyk, Turner, J.M., Baird, E.E., Dervan, P.B. & Rees, D.C., A structural basis for recognition of A-T and T-A base pairs in the minor groove of B-DNA, Science 282, 111-115 (1998).

2. Buttinelli, M., Minnock, A., Panetta, G., Waring, M. & Travers, A., The exocyclic groups of DNA modulate the affinity and positioning of the histone octamer. Proc. Nat. Acad. Sci. (USA) 95, 8544-8549 (1998).

 

(10) THURSDAY, APRIL 29 — Xiaoping Zhang

GENOMIC APPROACHES

1. Winzeler, E.A., Richards, D.R., Conway, A.R., Goldstein, A.L., Kalman, S., McCullough, M.J., McCusker, J.H., Stevens, D.A., Wodicka, L., Lockhart, D.H. & Davis, R.W., Direct allelic variation scanning of the yeast genome, Science 281, 1194-1197 (1998).

2. Zarembinski, T.I., Hung, L.-W., Muller-Dieckmann, H.-J., Kim, K.-K., Yokota, H., Kim, R. & Kim, S.-H., Structure-based assignment of the biochemical function of a hypothetical protein: A test case of structural genomics, Proc. Nat. Acad. Sci. (USA) 95, 15189-15193 (1998).