PRESENTATION TOPICS

G25.1815

MACROMOLECULAR STRUCTURE

FALL 2005

INSTRUCTIONS FOR PRESENTATIONS:

[1] EVERYBODY WILL HAVE A TOTAL OF 18 MINUTES. PLEASE COME TO CLASS AS EARLY AS POSSIBLE, BECAUSE IF EVERYONE IS THERE WE CAN START. WE WILL START WHEN EVERYONE IS THERE, OR 3:30, WHICHEVER COMES FIRST.

[2] PLAN TO SPEND NO MORE THAN 13 MINUTES ON YOUR TALK. THE REST OF THE TIME IS FOR DISCUSSION. I WILL CUT YOU OFF AFTER 13 MINUTES.

[3] YOU SHOULD USE GRAPHICS TO ILLUSTRATE THE IMPORTANT FIGURES AND POINTS IN THE PAPER. THESE SHOULD BE DERIVED FROM THE ORIGINAL PUBLICATION. IF FIGURES ARE IN COLOR IN THE ORIGINAL, YOUR OVERHEADS, IF YOU MAKE THEM, SHOULD BE IN COLOR, AS WELL. START LOOKING FOR YOUR ARTICLES NOW. IF THEY ARE HARD TO FIND IN THE E-JOURNALS AT BOBST, TELL ME. IF YOU START PREPARING YOUR PRESENTATION THE NIGHT BEFORE YOUR TALK, YOU MAY HAVE ONLY GARBAGE TO SHOW. IF YOU USE OVERHEADS, POINT ON THE SCREEN, NOT ON THE PROJECTOR.

[4] EVERYBODY IS RESPONSIBLE FOR EVERY PAPER. THAT IS WHY WE HAVE 5 MINUTES OF DISCUSSION SCHEDULED. YOU WILL BE GRADED ON YOUR DISCUSSION PARTICIPATION. EVERYBODY STARTS WITH A DISCUSSION GRADE OF 'C', A FAILING GRADE FOR A GRADUATE STUDENT. HOWEVER, IF YOU ASK A DUMB QUESTION, INDICATING THAT YOU HAVE NOT READ THE ARTICLE, YOU WILL GET A GRADE BELOW 'C'. GOOD QUESTIONS DO NOT REPEAT WHAT THE SPEAKER JUST SAID, BUT INVOLVE CLARIFICATION OF POINTS RAISED. IF I AM UNSATISFIED WITH THE QUALITY OF DISCUSSION, I WILL GIVE A FINAL EXAM ON THE CONTENT OF THE PAPERS. OTHERWISE I WON'T.

[5] PRACTICE YOUR TALK AT LEAST 30 TIMES!!!

(1) THURSDAY, DEC 07

Ribosome Structure -- Nancy Hom

1. M. Selmer, C.M. Dunham, F.V. Murphy, A. Weixbaumer, S. Petry, A.C. Kelley, J.R., Weir, V. Ramakrishnan, Structure of the 70S ribosome complexed with mRNA and tRNA, Science 313, 1935-1942 (2006).

(2) THURSDAY, DEC 07

Multi-drug Transporter Structure -- Claire Lee

2. S. Murakami, R. Nakashima, E. Yamashita, T. Matsumoto, A. Yamaguchi, Crystal structures of a multi-drug transporter reveal a functionally rotating mechanism, Nature 443, 173-179 (2006).

(3) THURSDAY, DEC 07

Channel Proteins -- Anuttara Udomprasert

3. M. Pioletti, F. Findeisen, G.L. Hura, D.L. Minor, Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer, Nature Str. & Mol. Biol., 13, 987-995 (2006).

(4) THURSDAY, DEC 07

Kasugamycin Inhibition of Protein Synthesis -- Kyungmin Chung

4. F. Schluenzen, C. Takemoto, D.N.Wilson, T. Kaminishi, J.M. Harms, K. Hanawa-Suetsugu, W. Szaflarski, M. Kawazoe, M. Shirouzo, K.H. Niedhaus, S. Yokoyama, P. Fucini, The antibiotic kasugamycin mimics mRNA nuceotides to destabiliz tRNA binding and hinhibit canonical translation initiation, Nature Str. & Mol. Biol. 13, 871-878 (2006).

(5) TUESDAY, DEC 12

Riboswitches -- Stephanie Geggier

5. N. Sudarsan, M.C. Hammond, K.F. Block, R. Welz, J.E. Barrick, A. Roth, R.R. Breaker, Tandem riboswitch architectures exhibit complex gene control functions, Science 314, 300-304 (2006).

(6) TUESDAY, DEC 12

DNA Hydrogels -- Bishwajit Paul

6. S.H. Um, J.B. ee, N. Park, S.Y. Kwon, C.C. Umbach, D. Luo, Enzyme-catalysed assembly of DNA hydrogel, Nature Materials 5, 797-801 (2006).

(7) TUESDAY, DEC 12

CCA-Adding Enzyme -- Christopher Ovanez

7. K. Tomita, R. Ishitani, S. Fukai, O. Nureki, Complete crystallographic analysis of the dynamics of CCA sequence addition, Nature 443, 956-960 (2006).

(8) TUESDAY, DEC 12

DNA Origami -- Sullivan Zheng

8. P.W.K. Rothemund, Folding DNA to create nanoscale shapes and patterns, Nature 440, 297-302 (2006).