PRESENTATION TOPICS

G25.1815

MACROMOLECULAR STRUCTURE

FALL 2005

INSTRUCTIONS FOR PRESENTATIONS:

[1] EVERYBODY WILL HAVE A TOTAL OF 18 MINUTES. PLEASE COME TO CLASS AS EARLY AS POSSIBLE, BECAUSE IF EVERYONE IS THERE WE CAN START. WE WILL START WHEN EVERYONE IS THERE, OR 3:30, WHICHEVER COMES FIRST.

[2] PLAN TO SPEND NO MORE THAN 13 MINUTES ON YOUR TALK. THE REST OF THE TIME IS FOR DISCUSSION. I WILL CUT YOU OFF AFTER 13 MINUTES.

[3] YOU SHOULD USE GRAPHICS TO ILLUSTRATE THE IMPORTANT FIGURES AND POINTS IN THE PAPER. THESE SHOULD BE DERIVED FROM THE ORIGINAL PUBLICATION. IF FIGURES ARE IN COLOR IN THE ORIGINAL, YOUR OVERHEADS, IF YOU MAKE THEM, SHOULD BE IN COLOR, AS WELL. START LOOKING FOR YOUR ARTICLES NOW. IF THEY ARE HARD TO FIND IN THE E-JOURNALS AT BOBST, TELL ME. IF YOU START PREPARING YOUR PRESENTATION THE NIGHT BEFORE YOUR TALK, YOU MAY HAVE ONLY GARBAGE TO SHOW. IF YOU USE OVERHEADS, POINT ON THE SCREEN, NOT ON THE PROJECTOR.

[4] EVERYBODY IS RESPONSIBLE FOR EVERY PAPER. THAT IS WHY WE HAVE 5 MINUTES OF DISCUSSION SCHEDULED. YOU WILL BE GRADED ON YOUR DISCUSSION PARTICIPATION. EVERYBODY STARTS WITH A DISCUSSION GRADE OF 'C', A FAILING GRADE FOR A GRADUATE STUDENT. HOWEVER, IF YOU ASK A DUMB QUESTION, INDICATING THAT YOU HAVE NOT READ THE ARTICLE, YOU WILL GET A GRADE BELOW 'C'. GOOD QUESTIONS DO NOT REPEAT WHAT THE SPEAKER JUST SAID, BUT INVOLVE CLARIFICATION OF POINTS RAISED. IF I AM UNSATISFIED WITH THE QUALITY OF DISCUSSION, I WILL GIVE A FINAL EXAM ON THE CONTENT OF THE PAPERS. OTHERWISE I WON'T.

[5] PRACTICE YOUR TALK AT LEAST 30 TIMES!!!

(1) TUESDAY, NOV 29

Myosin Structure -- Stephen Cole

1. J.L. Woodhead, F.-Q. Zhao, R. Craig, E.H. Egelman, L. Alamo & R. Padron, Atomic model of a myosin filament in the relaxed state. Nature 436, 1195-1199 (2005).

(2) TUESDAY, NOV 29

Nitrogenase Structure -- Dadong Li

2. F.A. Tezcan, J.T. Kaiser, D. Mustafi, M.Y. Walton, J.B. Howard & D.C. Rees, Nitrogenase Complexes: Multiple docking sites for a nucleotide switch protein, Science 309, 1377-1380 (2005).

(3) TUESDAY, NOV 29

Amyloid-Like Fibrils -- Anne Young

3. S. Sambashivan, Y. Liu, M.R. Sawaya, M. Gingery & D. Eisenberg, Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure, Naure 437, 166-269 (2005).

(4) TUESDAY, NOV 29

Complement Structure -- Tosan Omabegho

4. B.J.C. Janssen, E.G. Huizing, H.C.A. Raaijmakers, A. Roos., M.R. Daha, K. Nilsson-Ekdahl, B. Nilsson & Piet Gros, Structures of complement component C3 provide insights into the function and evolution of immunity, Nature 437, 505-511 (2005).

(5) THURSDAY, DEC 01

Single Molecule Protein Folding -- Wenyan Liu

5. C. Cecconi, E.A. Shank, C. Bustamante & S. Marqusee, Direct observation of the three-state folding of a single protein molecule, Science 309, 2057=2060 (2005).

(6) THURSDAY, DEC 01

Cell Death -- Yun Kyung Kim

6. N. Yan, J. Chai, E.S. Lee, L. Gu, Q. Liu, J. He, J.-W. Wu, D. Kokel, H. Li, Q. Hao, D. Sue & Y. Shi, Structure of the CED-4-CED-9 complex provides insights into programmed cell death in C. elegans, Nature 437, 831-837 (2005).

(7) THURSDAY, DEC 01

B-Z Junction -- Tanashaya Ciengshin

7. S.C. Ha, K. Lowenhaupt, A. Rich, Y.-G. Kim & K.K. Kim, Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases, Nature 437, 1183-1186 (2005).